METABOLISM OF CORTISONE BY RAT LIVER HOMOGENATE
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چکیده
منابع مشابه
5-hydroxytryptamine Metabolism by the Nuclear Fraction of Rat-liver Homogenate.
1. The metabolism of 5-hydroxy[1'-(14)C]tryptamine creatinine sulphate in the nuclear fraction of rat-liver homogenate was studied. In the incubation mixture five metabolites were found. 2. Two metabolites were not radioactive; one of them was identified as 5-hydroxyindole-3-carboxylic acid and the second tentatively as 5-hydroxyindole-3-aldehyde. 3. 5-Hydroxyindol-3-ylacetic acid, 1'-N-acetyl-...
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By using a highly specific radioimmunoassay the formation of tri-iodothyronine by the deiodination of thyroxine was studied in rat liver homogenate. Several observations suggest that the reaction observed is enzymic in nature. Pre-heating the homogenate for 30 min at 56 degrees C completely abolished conversion of thyroxine into tri-iodothyronine; the component of rat liver homogenate responsib...
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An investigation of the effect of cortisone administration upon the chemical composition of intracellular particulates of rat liver has been made. Livers were homogenized in 0.25 M sucrose solutions and submitted to differential centrifugation. Five fractions were prepared: mitochondria (Mit), microsomes (Mi), ultracentrifugable (U), non-sedimentable (S), and nuclear (Nuc). Measurement was made...
متن کاملEffects of Cortisone on Rat Liver Mitochondria
Experiments were designed to determine the effects of parenteral administration of cortisone on mitochondrial numbers of rat liver cells. Observations were made in three ways: (1) after osmic acid fixation and appropriate stain, (2) by phase microscopy on intact cells, (3) by actual enumeration of mitochondria and nuclei to provide data on mitochondria per cell. The results of the experiments i...
متن کاملEffects of Cortisone on Rat Liver Mitochondria* by Charles Upton
Biochemical studies indicate that a substantial decrease in mitochondrial ribonucleic acid (RNA) of rat liver cells occurs following parenteral administration of large doses of cortisone acetate (1). Reports have appeared indicating that carcinogens can also affect mitochondrial RNA content as well as their number (2, 3), while virus invasion of a cell alters mitochondrial morphology (4). Mitoc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1955
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65980-0